diff --git a/bot/api.py b/bot/api.py
index ef65f00..a47a232 100644
--- a/bot/api.py
+++ b/bot/api.py
@@ -307,6 +307,13 @@ def set_language_mode(language: str = "english"):
     model_used = globals.JAPANESE_TEXT_MODEL if language.lower() == "japanese" else globals.TEXT_MODEL
     logger.info(f"Language mode set to {language.lower()} (using {model_used})")
     
+    # Persist so it survives restarts
+    try:
+        from config_manager import config_manager
+        config_manager.set("discord.language_mode", language.lower(), persist=True)
+    except Exception:
+        pass
+    
     return {
         "status": "ok",
         "language_mode": language.lower(),
@@ -2963,6 +2970,14 @@ def set_voice_debug_mode(enabled: bool = Form(...)):
     """Set voice debug mode (shows transcriptions and responses in text channel)"""
     globals.VOICE_DEBUG_MODE = enabled
     logger.info(f"Voice debug mode set to: {enabled}")
+    
+    # Persist so it survives restarts
+    try:
+        from config_manager import config_manager
+        config_manager.set("voice.debug_mode", enabled, persist=True)
+    except Exception:
+        pass
+    
     return {
         "status": "ok",
         "debug_mode": enabled,
@@ -3004,6 +3019,14 @@ async def toggle_cat_integration(enabled: bool = Form(...)):
     """Toggle Cheshire Cat integration on/off."""
     globals.USE_CHESHIRE_CAT = enabled
     logger.info(f"🐱 Cheshire Cat integration {'ENABLED' if enabled else 'DISABLED'}")
+    
+    # Persist so it survives restarts
+    try:
+        from config_manager import config_manager
+        config_manager.set("memory.use_cheshire_cat", enabled, persist=True)
+    except Exception:
+        pass
+    
     return {
         "success": True,
         "enabled": globals.USE_CHESHIRE_CAT,
diff --git a/bot/bot.py b/bot/bot.py
index f032c38..27ce63e 100644
--- a/bot/bot.py
+++ b/bot/bot.py
@@ -105,6 +105,10 @@ async def on_ready():
     from utils.bipolar_mode import restore_bipolar_mode_on_startup
     restore_bipolar_mode_on_startup()
 
+    # Restore runtime settings (language, debug flags, etc.) from config_runtime.yaml
+    from config_manager import config_manager
+    config_manager.restore_runtime_settings()
+
     # Initialize DM interaction analyzer
     if globals.OWNER_USER_ID and globals.OWNER_USER_ID != 0:
         init_dm_analyzer(globals.OWNER_USER_ID)
diff --git a/bot/config_manager.py b/bot/config_manager.py
index cb2daa2..3c5fdc0 100644
--- a/bot/config_manager.py
+++ b/bot/config_manager.py
@@ -102,6 +102,54 @@ class ConfigManager:
         except Exception as e:
             logger.error(f"❌ Failed to load GPU state: {e}")
 
+    def restore_runtime_settings(self):
+        """
+        Restore persisted runtime settings from config_runtime.yaml into globals.
+
+        Called once at startup (in on_ready) so that settings changed via the
+        Web UI or API survive bot restarts.
+
+        Settings with their own persistence (EVIL_MODE, BIPOLAR_MODE) are
+        handled by their respective modules and are intentionally skipped here.
+        """
+        import globals as g
+
+        # Map: config_runtime.yaml key path -> (globals attribute, converter)
+        _SETTINGS_MAP = {
+            "discord.language_mode":    ("LANGUAGE_MODE",     str),
+            "autonomous.debug_mode":    ("AUTONOMOUS_DEBUG",  bool),
+            "voice.debug_mode":         ("VOICE_DEBUG_MODE",  bool),
+            "memory.use_cheshire_cat":  ("USE_CHESHIRE_CAT",  bool),
+            "gpu.prefer_amd":           ("PREFER_AMD_GPU",    bool),
+        }
+
+        restored = []
+
+        for key_path, (attr, converter) in _SETTINGS_MAP.items():
+            value = self._get_nested_value(self.runtime_config, key_path)
+            if value is not None:
+                try:
+                    setattr(g, attr, converter(value))
+                    restored.append(f"{attr}={getattr(g, attr)}")
+                except (ValueError, TypeError) as exc:
+                    logger.warning(f"⚠️  Could not restore {key_path}: {exc}")
+
+        # DM mood needs special handling (load description too)
+        dm_mood = self._get_nested_value(self.runtime_config, "runtime.mood.dm_mood")
+        if dm_mood and isinstance(dm_mood, str) and dm_mood in getattr(g, "AVAILABLE_MOODS", []):
+            g.DM_MOOD = dm_mood
+            try:
+                from utils.moods import load_mood_description
+                g.DM_MOOD_DESCRIPTION = load_mood_description(dm_mood)
+            except Exception:
+                g.DM_MOOD_DESCRIPTION = f"I'm feeling {dm_mood} today."
+            restored.append(f"DM_MOOD={dm_mood}")
+
+        if restored:
+            logger.info(f"🔄 Restored {len(restored)} runtime settings: {', '.join(restored)}")
+        else:
+            logger.debug("ℹ️  No runtime settings to restore")
+
     def get(self, key_path: str, default: Any = None) -> Any:
         """
         Get configuration value with priority system.